Bridging Gaps in Research

Through a coordinated research effort involving patients, clinicians and researchers, the Brain Inflammation Collaborative strives to uncover connections between brain inflammation and mental and physical health and make advances in the diagnosis, treatment and prevention of neuroinflammatory illness.

Uncover hidden connections between inflammation and mental health with patient-reported outcomes that leverage wearables, and validated assessments on the Unhide™ Platform for groundbreaking research insights.

The Unhide Project is an ongoing online clinical study that assembles patient-donated data to help clinicians and researchers accelerate breakthroughs surrounding brain inflammation and mental health.

Join the Movement

The relationship between brain inflammation and mental health is vastly understudied and misunderstood. The Brain Inflammation Collaborative is leading the charge to change that. Discover all the different ways you can support our mission to find long-overdue answers and solutions for patients.

Many named disorders are thought to be related to brain inflammation. A person with brain inflammation may have one of these diagnoses as well — in which case it is called a “comorbidity.”  Frequently, other people in the family have diagnoses from this list too, a clue that genetic factors may be at play.

Conditions often accompanying inflammatory brain disease

Chronic brain inflammation is associated with a wide range of disorders. Some of these are neurobehavioral, but many affect the whole body too. Even the disorders with mostly neurobehavioral symptoms vary a lot depending on which areas of the brain are affected. Scientists are now trying to understand the role of inflammation in these illnesses, but more research is needed. 


Disorders that are mostly neurobehavioral 

  • mood disorders
  • depression
  • eating disorders (anorexia nervosa, bulimia nervosa, and binge eating disorder)
  • obsessive compulsive disorder (OCD)
  • tic disorders
  • ADHD
  • PTSD
  • narcolepsy
  • autoimmune encephalitis
  • autism spectrum disorders
  • bipolar disorder
  • psychotic disorders and schizophrenia
  • Parkinsons
  • multiple sclerosis
  • Alzheimers

Disorders involving the rest of the body:

  • lupus
  • long COVID
  • rheumatoid arthritis and other forms of arthritis
  • POTS (Post Orthostatic Tachycardia Syndrome) 
  • EDS (Ehlers Danlos Syndrome)
  • MCAS (mast cell activation syndrome)
  • thyroid disease
  • psoriasis and psoriatic arthritis
  • Sjogrens disease
  • Bechet’s disease
  • Inflammatory bowel disease
  • rheumatic fever
  • other autoimmune illnesses
  • immune deficiencies

Need for research: the Unhide™ Project

Our vision is for brain inflammation disorders to be easily diagnosed by medical professionals and to find accessible therapies. 

To support research in this area we developed the Unhide™ Project, a longitudinal and historical research registry and bio repository platform to study the potential immunological mechanisms driving chronic brain inflammation in order to find new therapeutic targets.

Research is critical to evolve current therapies and develop new treatment targets

The Unhide™ Project was established to collect lab samples from patients with diseases characterized by brain inflammation in order to compare and understand common biomarkers.

You can mail a check (payable to Brain Inflammation Collaborative, Inc.) with your donation any time to the following address:

Brain Inflammation Collaborative, Inc.
925 Genesee St #180440
Delafield, WI 53018