Bridging Gaps in Research

Through a coordinated research effort involving patients, clinicians and researchers, the Brain Inflammation Collaborative strives to uncover connections between brain inflammation and mental and physical health and make advances in the diagnosis, treatment and prevention of neuroinflammatory illness.

Uncover hidden connections between inflammation and mental health with patient-reported outcomes that leverage wearables, and validated assessments on the Unhide™ Platform for groundbreaking research insights.

The Unhide Project is an ongoing online clinical study that assembles patient-donated data to help clinicians and researchers accelerate breakthroughs surrounding brain inflammation and mental health.

Join the Movement

The relationship between brain inflammation and mental health is vastly understudied and misunderstood. The Brain Inflammation Collaborative is leading the charge to change that. Discover all the different ways you can support our mission to find long-overdue answers and solutions for patients.

A single standard of care for chronic brain inflammation has not been clearly established; instead, patients do best with individualized care. Usually a multidisciplinary approach to treatment is needed, with collaboration between neurologists, rheumatologists, psychiatrists, and immunologists and approaches from medication to counseling.

Treatments for brain inflammation

Treatment strategies vary greatly and depend on the specific set of symptoms presented by each unique patient. Medications for post-infectious or autoimmune inflammation can include:

  • antibiotics
  • antivirals
  • antidepressants and antipsychotics
  • nonsteroidal anti-inflammatory drugs
  • corticosteroids
  • intravenous immunoglobulin (IVIg)
  • immunosuppressants
  • biologics
  • plasma exchange 

When psychiatric symptoms are unusually resistant to psychiatric medications, consider the possibility of an inflammatory process. This is supported by the fact that immune modulation can improve symptoms independent of psychiatric medications in patients with neuroinflammation.

Emotional, psychological and social support

Non-pharmacological treatments are often used as first-line therapies, particularly when the underlying cause of brain inflammation is unknown. These may include:

  • Psychological counseling services such as cognitive-behavioral therapy
  • Nutritional therapy
  • Occupational and physical therapy
  • Academic support
  • Family counseling and supportive services

Along with other lifestyle adjustments, these interventions can help make daily life a little easier.

That said, it is critical to address the underlying causes of brain inflammation.

Immune modulation: the future of treating brain inflammation?

When autoimmune processes are suspected, treatments addressing the immune system are typically recommended as a first-line treatment. However, the challenge of brain inflammation is understanding—and acknowledging—any immunological underpinnings.

New investigations seek to improve diagnosis, including the use of blood cytokine markers, genetic testing, and large data science repositories to track disease. Research into treatments addressing immune dysregulation, including monoclonal antibodies, give hope for those with brain inflammation.  The aim is healthier outcomes for future generations.

Need for research: the Unhide™ Project

Our vision is for brain inflammation disorders to be easily diagnosed by medical professionals and to find accessible therapies. 

To support research in this area we developed the Unhide™ Project, a longitudinal and historical research registry and bio repository platform to study the potential immunological mechanisms driving chronic brain inflammation in order to find new therapeutic targets.

Research is critical to evolve current therapies and develop new treatment targets

The Unhide™ Project was established to collect lab samples from patients with diseases characterized by brain inflammation in order to compare and understand common biomarkers.

You can mail a check (payable to Brain Inflammation Collaborative, Inc.) with your donation any time to the following address:

Brain Inflammation Collaborative, Inc.
925 Genesee St #180440
Delafield, WI 53018