Bridging Gaps in Research

Through a coordinated research effort involving patients, clinicians and researchers, the Brain Inflammation Collaborative strives to uncover connections between brain inflammation and mental and physical health and make advances in the diagnosis, treatment and prevention of neuroinflammatory illness.

Uncover hidden connections between inflammation and mental health with patient-reported outcomes that leverage wearables, and validated assessments on the Unhide™ Platform for groundbreaking research insights.

The Unhide Project is an ongoing online clinical study that assembles patient-donated data to help clinicians and researchers accelerate breakthroughs surrounding brain inflammation and mental health.

Join the Movement

The relationship between brain inflammation and mental health is vastly understudied and misunderstood. The Brain Inflammation Collaborative is leading the charge to change that. Discover all the different ways you can support our mission to find long-overdue answers and solutions for patients.


A New Era of Research Needed

Inflammation occurs when the immune system detects injury, infection, or tissue damage. During an inflammatory response, the body sends white blood cells, hormones, and nutrients to the affected area to fight off any potential threats and repair damaged tissue. While this is a healthy and necessary defense mechanism, it typically presents as short-term pain, swelling, redness, warmth, or fever. 

However, inflammation is not always helpful. Sometimes it becomes chronic, causing health problems such as arthritis, heart disease, and cancer. Sometimes inflammation happens because the immune system is dysregulated and flares where it is not needed. In some illnesses, the immune system gets confused and attacks healthy parts of the body, referred to as autoimmunity.

In the brain, inflammation can affect how we think, act, feel and move. Whether triggered by an infection, injury, or autoimmune response, brain inflammation can cause diverse neurological and psychological symptoms and complications, from depression and anxiety to obsessive compulsive and movement disorders. For this reason, brain inflammation can be difficult to differentiate from other conditions. 

Neuroinflammatory conditions are subject to increasing interest inwithin medical research. However, there is still a great amount to learn about their causes, diagnosis, and treatment. The overlap between different conditions, commonalities in presentation, and connections between brain inflammation and mental health are relatively new areas of exploration. 

The connection between brain inflammation and mental health is often misunderstood and misdiagnosed. This is largely because: 

  • there hasn’t been enough research into brain inflammation (particularly infection-related illnesses) 
  • research has often tended to focus on individual conditions, rather than considering connections and similarities between conditions 
  • studies have failed to fully take account of patient experiences

Without robust, reliable evidence, the clinical community cannot properly diagnose and treat patients. As a result, many patients feel dismissed and end up without treatment. To revolutionize the diagnosis and treatment of neuroinflammatory illnesses, a new, coordinated, patient-centered approach to research is needed. 

At the Brain Inflammation Collaborative (BIC), we are on a mission to ensure that brain inflammation impacting mental health is properly diagnosed and treated. We do this by:

  • Collaborating with researchers, clinicians, and patients to share stories, data, information, and tools
  • Developing & supporting innovative research tools, methods, and projects 
  • Educating patients, clinicians, and others about the impact of brain inflammation on mental health through awareness and research

 2023, our main project at the Brain Inflammation Collaborative revolves around developing and supporting innovative research.  We are doing this through the development of the Unhide™ Project. Learn more about Unhide.

You can mail a check (payable to Brain Inflammation Collaborative, Inc.) with your donation any time to the following address:

Brain Inflammation Collaborative, Inc.
925 Genesee St #180440
Delafield, WI 53018