Bridging Gaps in Research

Through a coordinated research effort involving patients, clinicians and researchers, the Brain Inflammation Collaborative strives to uncover connections between brain inflammation and mental and physical health and make advances in the diagnosis, treatment and prevention of neuroinflammatory illness.

Uncover hidden connections between inflammation and mental health with patient-reported outcomes that leverage wearables, and validated assessments on the Unhide™ Platform for groundbreaking research insights.

The Unhide Project is an ongoing online clinical study that assembles patient-donated data to help clinicians and researchers accelerate breakthroughs surrounding brain inflammation and mental health.

Join the Movement

The relationship between brain inflammation and mental health is vastly understudied and misunderstood. The Brain Inflammation Collaborative is leading the charge to change that. Discover all the different ways you can support our mission to find long-overdue answers and solutions for patients.

Our Mission

Our mission is to assemble the largest patient-driven data and biosample resource to date to uncover the answers needed to further advancements in diagnosis, treatment and prevention of brain inflammation and mental health. Research has been underrepresented in this area and no long-term, real-world study has been done to track individuals suffering from brain inflammation and mental health issues. The Unhide™ Project is leading the charge to change that.

Researcher-level

Differential diagnoses of patients with neuroinflammatory diseases and the development of neuroinflammatory signatures through biomarker data and clinical markers.

Biomarker data

Improving access to biomarker data, through investigation of what biomarker data suggest for a neuroinflammatory diagnosis and the establishment of healthcare provider guidelines to appropriately order and interpret lab tests, for the following signatures:

  • Clinical lab “signatures” 
  • Autoantibody signatures
  • Cytokine signatures
  • Combination signatures of the above
  • Basic research – additional pathophysiological mechanisms and biomarker signatures, with a preference for those addressed by existing agents that can be repurposed
  • Development of diagnostic tools and scales

Clinical markers of differential diagnoses

  • Symptom/sign clusters,  including existence at any time, severity, and episodicity
  • Comorbidities/family history/demographics
  • Longitudinal history (associations between symptoms and events)

Recording and managing burden of disease and associated impacts on individuals and families.

Quantification of burden of disease

  • Quantification of disease burden and strongest drivers of decrease in function, caregiver stress, healthcare utilization 

Social impacts

  • Pharmacoeconomics to support cost-effectiveness of therapies 
  • Orphan disease designations 
  • Surveillance studies using other database along with IPEP-signatures to identify macro-epidemiological trends, like changes over time, geographic and socioeconomic trends, etc. 
  • Programs to enhance recruitment & retention of healthy controls

Understanding experiences as reported by patients, promoting proof-of-concept prospective clinical studies, and developing and validating animal models to support clinical studies for various types of therapies and patient self-care.

Therapies

Prescription medical therapies
Supportive professional therapies
Surgical therapies

Self-care through lifestyle actions and supplements

Understanding risk factors and triggers of symptom onset associated with development of neuroinflammatory diseases.

Genetic risk factors

Understanding genetic associations with diagnosis and clinical traits

Demographic/clinical risk factors

Understanding what demographic, clinical, or lifestyle factors are associated with development of or resistance to disease

Triggers of symptom onset

Lifestyle modifications to reduce triggers & impacts
Medical interventions to reduce triggers & impacts

Overall

Development and validation of animal models to support clinical studies

How does this affect me?

Our research roadmap on the individual level is based on patient-driven longitudinal data.

Differential diagnosis of patients with neuroinflammatory diseases and the development of neuroinflammatory signatures.

Biomarker data

Increasing accessibility to biomarker data by helping patients know what biomarker data suggest neuroinflammatory disease and how to order appropriate lab tests for the following signatures:

  • Clinical lab “signatures”
  • Autoantibody signatures
  • Cytokine signatures

 

Clinical markers of differential diagnoses

  • Comorbidities/family history/demographics
  • Longitudinal history – associations between symptoms and events

Recording and managing burden of disease and associated impacts on individuals and families.

Quantification of burden of disease

  • Functional (physical, mental, cognitive, and/or behavioral) impacts
  • Family impacts

Managing impacts

  • Record-keeping and case-making in support of insurance claims
  • Record-keeping and case-making in support of HCP understanding/guidance
  • Record-keeping and case-making in interactions with schools and employers
  • Managing stress in the family
  • Building community

What’s going on and how long will it last? Understanding condition/s, identifying promising therapies, and preventing additional episodes

Symptoms

  • Physical signs and symptoms
  • Psychological symptoms 
  • Cognitive symptom

Therapies

  • Prescription medical therapies
  • Supportive professional therapies
  • Surgical therapies

Self-care through lifestyle actions and supplements

Understanding risk factors and triggers of symptom onset associated with the development of neuroinflammatory diseases.

Genetic risk factors 

Demographic/clinical risk factors 

Triggers of symptom onset

  • Lifestyle modifications to reduce triggers & impacts
  • Medical interventions to reduce triggers & impacts

You can mail a check (payable to Brain Inflammation Collaborative, Inc.) with your donation any time to the following address:

Brain Inflammation Collaborative, Inc.
925 Genesee St #180440
Delafield, WI 53018

https://braininflammation.org/wp-content/uploads/2023/06/Unhide_whitepaper_V4.pdf