Bridging Gaps in Research

Through a coordinated research effort involving patients, clinicians and researchers, the Brain Inflammation Collaborative strives to uncover connections between brain inflammation and mental and physical health and make advances in the diagnosis, treatment and prevention of neuroinflammatory illness.

The Unhide Project is an ongoing online clinical study that assembles patient-donated data to help clinicians and researchers accelerate breakthroughs surrounding brain inflammation and mental health.

Join the Movement

The relationship between brain inflammation and mental health is vastly understudied and misunderstood. The Brain Inflammation Collaborative is leading the charge to change that. Discover all the different ways you can support our mission to find long-overdue answers and solutions for patients.

The Connection Between Brain Inflammation and Mental Health

Whether the result of autoimmune processes, infection, allergy, or injury, brain inflammation can sometimes trigger or mimic common mental health symptoms like depression, anxiety, OCD, or even behavioral changes. This connection between brain inflammation and mental health is often neglected by healthcare providers leading to misdiagnosis, confusion, and delays in receiving appropriate care—or even the wrong care.

Looking for Clarity

Did you know brain inflammation and mental health symptoms can result from viral infections or even bacteria from an abscessed tooth or strep infection? And some autoimmune illnesses such as rheumatoid arthritis and POTS are now thought to have associations with brain inflammation. Even long COVID is being studied for connections to brain inflammation and mental health symptoms.

Understanding the connections between brain inflammation and mental health symptoms can be difficult and confusing for families, clinicians, and even researchers. As part of our research, we hope to identify ways to determine when brain inflammation is involved in the triggering of mental health symptoms. 

Some of the mental health symptoms we are investigating include:

  • Behavior changes
  • OCD
  • Abnormal restrictive eating behaviors
  • Depression
  • Anxiety disorders
  • Seizures
  • Brain fog or cognitive issues
  • Intrusive thoughts
  • Chronic fatigue
  • Motor and vocal tics
  • Light-headedness and/or dizziness
  • Joint or nerve pain


Inadequate research of immune correlations can create pain and anguish for these debilitating and mischaracterized mental health symptoms. The effects are devastating on the lives of patients and families— all too common of a story. But we feel strongly that the solution is hidden in plain sight. Our goal is to assemble the largest patient-driven data and biosample resource to date to uncover the answers needed to further advancements in diagnosis, treatment, and prevention.

Investigating Mental Health Connections Through Our Unhide™ Project

The Unhide™ Project is a simple-to-use online digital platform that tracks patient health stories, symptoms, life events, and bio-samples all in one place. We look to further advancements in diagnosis, treatment, and prevention of brain inflammation through this clinical research registry and biobank platform.

Our goal is to look for patterns and triggers in both mental and physical health data. However, we also hope this tool will help families ease the overall burden of collecting and organizing patient health care data—both for themselves and for sharing with healthcare providers.

The beginning phase of our ongoing research study will include people with a diagnosis or suspected diagnosis of one or more of the following:

  • Long-haul COVID 
  • POTS 
  • ME/CFS
  • OCD
  • Anorexia nervosa
  • Tourette syndrome
  • Narcolepsy
  • Autoimmune encephalitis


Subsequent phases of illness diagnoses will include:

  • Depression
  • Anxiety disorders
  • PTSD
  • Concussion
  • Stroke
  • Suicide
  • Rheumatoid arthritis
  • Ehlers Danlos syndrome (EDS)
  • Mast cell activation syndrome (MCAS)
  • Chronic sinusitis
  • Small fiber neuropathy
  • Psoriasis
  • Irritable bowel disease (IBD)


Mental health and brain inflammation research has been underrepresented for far too long. No long-term, real-world study has ever been done to track individuals suffering from brain inflammation and mental health issues. By participating in the Unhide™ Project, you will join a large, collaborative effort to help us learn about mental health symptoms that we feel are driven by brain inflammation.

Visit the Unhide™ Project to learn more about eligibility and the benefits of joining our project.

You can mail a check (payable to Brain Inflammation Collaborative, Inc.) with your donation any time to the following address:

Brain Inflammation Collaborative, Inc.
925 Genesee St #180440
Delafield, WI 53018